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Indication & Dosage |
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| Oral |
| TREATMENT OF HYPERCHOLESTEROLAEMIA |
| Adult:
Usual starting dose: Atorvastatin 10 mg + ezetimibe 10 mg once daily. |
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| Precautions |
Hepatic impairment; patients consuming substantial quantities of alcohol with a history of liver disease. |
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| Adverse Drug Reactions |
Atorvastatin: Headache, flatulence, dyspepsia, myalgia, rash, pruritus, allergy and infection. Ezetimibe: Abdominal discomfort, headache, diarrhoea, back pain, arthralgia, resp infection and fatigue. |
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| Interactions |
Antacids decrease atorvastatin levels; colestipol decreases atorvastatin plasma levels; propranolol decreases antihyperlipidaemic activity of atorvastatin. Atorvastatin: Increases digoxin levels; increases anticoagulant effect of warfarin. Avoid the combination of HMG-CoA reductase inhibitors and fibrates. Ezetimibe: Cholestyramine decreases AUC of ezetimibe by approx 55%; ciclosporin may increase ezetimibe levels. |
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